足月孕妇宫颈阴道分泌物中胎儿纤连蛋白和细胞因子检测在预测足月分娩和过期妊娠中的意义
Significance of fetal fibronectin and cytokine measurement in the cervicovaginal secretions of women at term in predicting term labor and post-term pregnancy.
作者信息
Imai M, Tani A, Saito M, Saito K, Amano K, Nisijima M
机构信息
Department of Obstetrics and Gynecology, Kitasato University School of Medicine, 1-15-1, Kitasato Sagamihara, Kanagawa, Japan.
出版信息
Eur J Obstet Gynecol Reprod Biol. 2001 Jul;97(1):53-8. doi: 10.1016/s0301-2115(00)00483-8.
OBJECTIVE
To determine whether fetal fibronectin (FFN) or cytokine concentrations in cervicovaginal secretions can be used to predict term labor and post-term pregnancy.
STUDY DESIGN
FFN and cytokines were assayed in cervicovaginal mucus from 122 pregnant women at 29-35 weeks and weekly from week 36 to parturition.
RESULTS
FFN concentrations were elevated from about 3 weeks before parturition; a correlation was found between FFN levels and sampling-to-delivery intervals. Parturition was best predicted within 7 days of sampling when the FFN value was >or=50ng/ml between 36 and 41 gestational weeks. Interleukin-1beta (IL-1beta) concentrations were elevated from 3 to 4 weeks before parturition; a correlation was found between IL-1beta levels and sampling-to-delivery intervals. Parturition was best predicted within 7 days of sampling, with an IL-1beta cut-off value of >or=100pg/ml.
CONCLUSION
Term labor and post-term pregnancy can be predicted within 7 days of sampling, using FFN and IL-1beta concentrations in cervicovaginal secretions of pregnant women.
目的
确定宫颈阴道分泌物中的胎儿纤连蛋白（FFN）或细胞因子浓度是否可用于预测足月分娩和过期妊娠。
研究设计
对122名孕周为29 - 35周的孕妇的宫颈阴道黏液进行FFN和细胞因子检测，并从孕36周开始至分娩每周检测一次。
结果
FFN浓度在分娩前约3周开始升高；FFN水平与采样至分娩间隔之间存在相关性。当孕36至41周时FFN值≥50ng/ml时，在采样后7天内预测分娩效果最佳。白细胞介素-1β（IL-1β）浓度在分娩前3至4周开始升高；IL-1β水平与采样至分娩间隔之间存在相关性。当IL-1β临界值≥100pg/ml时，在采样后7天内预测分娩效果最佳。
结论
利用孕妇宫颈阴道分泌物中的FFN和IL-1β浓度，可在采样后7天内预测足月分娩和过期妊娠。
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