Silverberg S G, Haukkamaa M, Arko H, Nilsson C G, Luukkainen T
Int J Gynecol Pathol. 1986;5(3):235-41. doi: 10.1097/00004347-198609000-00005.
Levonorgestrel-releasing intrauterine devices (IUD) were inserted in 92 women. Endometrial biopsies were taken between 3 months and 7 years after these insertions. Intrauterine release of levonorgestrel resulted in endometrial glandular atrophy and decidualized stroma. Inflammation and necrosis were also seen as local signs of IUD use. The biopsies were similar regardless of the duration of IUD use. Endometrial morphology returned to normal in biopsy specimens taken 1-3 months after IUD removal.
92名女性植入了左炔诺孕酮宫内节育器（IUD）。在植入后的3个月至7年期间进行了子宫内膜活检。宫内释放左炔诺孕酮导致子宫内膜腺体萎缩和间质蜕膜样变。炎症和坏死也被视为使用IUD的局部表现。无论IUD使用时间长短，活检结果相似。在取出IUD后1 - 3个月采集的活检标本中，子宫内膜形态恢复正常。
