Nilsson C G, Luukkainen T, Arko H
Fertil Steril. 1978 Apr;29(4):397-401. doi: 10.1016/s0015-0282(16)43212-7.
Endometrial biopsies were obtained from 12 volunteers treated with d-norgestrel-releasing intrauterine devices (IUDs) with two different release rate. Four subjects scheduled for hysterectomy had d-norgestrel-releasing IUDs inserted approximately 1 month prior to surgery. The effect of d-norgestrel on the endometrium and fallopian tubes of the removed uteri was examined. A uniform suppression of the endometrium with glandular atrophy and decidualization of the stroma was found in all of the endometrial specimens. Moreover, changes similar to those observed during the luteal phase and early pregnancy could be seen in the tubal epithelium.
从12名使用两种不同释放速率的左炔诺孕酮宫内节育器（IUD）治疗的志愿者身上获取子宫内膜活检样本。4名计划进行子宫切除术的受试者在手术前约1个月插入了左炔诺孕酮释放IUD。研究了左炔诺孕酮对切除子宫的子宫内膜和输卵管的影响。在所有子宫内膜样本中均发现子宫内膜受到均匀抑制，伴有腺体萎缩和间质蜕膜化。此外，在输卵管上皮中可见到与黄体期和早孕期间观察到的变化相似的改变。
