Spaeth G L, Mutlukan E
J Glaucoma. 2001 Jun;10(3):145-51. doi: 10.1097/00061198-200106000-00001.
To examine why most ophthalmologists routinely use mitomycin C or 5-fluorouracil (antimetabolites) in association with filtering surgery for glaucoma.
Critical analysis of seven medical, social and economic trends.
The rapid acceptance of the adjunctive use of antimetabolites at the time of filtration surgery may be explained by reasons other than anticipated increase in the "success" of glaucoma surgery.
The use of antimetabolites in conjuction with filtering glaucoma surgery may be at least partially a consequence of changing medical-social-economic factors, rather than solely a desire on the part of physicians to improve the "success" of glaucoma surgery. This may indicate a need to reevaluate the proper place of antimetabolites in association with filtration surgery.
探讨为何大多数眼科医生在青光眼滤过手术中常规使用丝裂霉素C或5-氟尿嘧啶（抗代谢药物）。
对七种医学、社会和经济趋势进行批判性分析。
滤过手术时辅助使用抗代谢药物迅速得到认可，其原因可能并非预期的青光眼手术“成功率”提高。
青光眼滤过手术联合使用抗代谢药物可能至少部分是医疗-社会-经济因素变化的结果，而不仅仅是医生想要提高青光眼手术“成功率”的愿望。这可能表明需要重新评估抗代谢药物在滤过手术中的适当位置。
