Jansson L, Lavstedt S, Frithiof L, Theobald H
Department of Periodontology at Skanstull, Folktandvården, Götgatan 100, County of Stockholm, S-118 62 Stockholm, Sweden.
J Clin Periodontol. 2001 Aug;28(8):762-8. doi: 10.1034/j.1600-051x.2001.280807.x.
BACKGROUND, AIMS: The purpose of the study was to investigate the relationship between periodontal health and fatal cardiovascular diseases (CVD).
The investigation was conducted on a sample of 1393 individuals in the County of Stockholm. The subjects were examined in an epidemiological study in 1970 with respect to dental health. At a follow-up in 1997, the mortality rate of the sample during the years 1970-1996 was registered as well as cause of death according to the death certificate. Stepwise logistic regression analysis was performed in order to evaluate the influence of the investigated variables on the incidence of death from CVD.
The interactional effect between plaque and oral health score (a sum of scores for number of missing teeth, apical lesions, caries lesions and marginal bone loss), adjusted for age, gender, smoking and CVD at baseline, was significantly correlated to fatal coronary events. For individuals younger than 45 years of age, the age-adjusted incidence odds ratio of death due to CVD was 2.7 (p=0.04) if subjects with mean marginal bone loss of >10% were compared with subjects with mean marginal bone loss < or =10 %. If the stratum of individuals <45 years of age is confined to smokers, the odds ratio was found to be 3.4 (p=0.03).
Dental health was found to be a risk indicator of death due to CVD, especially in combination with another risk factor, smoking habits.
背景、目的：本研究旨在调查牙周健康与致命性心血管疾病（CVD）之间的关系。
对斯德哥尔摩县的1393名个体进行了调查。1970年在一项流行病学研究中对这些受试者的牙齿健康状况进行了检查。在1997年的随访中，记录了该样本在1970年至1996年期间的死亡率以及根据死亡证明确定的死亡原因。进行了逐步逻辑回归分析，以评估所研究变量对CVD死亡发生率的影响。
在对年龄、性别、吸烟和基线时的CVD进行校正后，菌斑与口腔健康评分（缺失牙数量、根尖病变、龋损和边缘骨丧失评分之和）之间的交互作用与致命性冠状动脉事件显著相关。对于年龄小于45岁的个体，如果将平均边缘骨丧失>10%的受试者与平均边缘骨丧失≤10%的受试者进行比较，CVD导致的年龄校正死亡发生率比值比为2.7（p = 0.04）。如果将年龄<45岁的个体层限定为吸烟者，比值比为3.4（p = 0.03）。
牙齿健康被发现是CVD导致死亡的一个风险指标，尤其是与另一个风险因素吸烟习惯相结合时。
