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死亡率与口腔健康 - 斯德哥尔摩县 44 年的队列研究。

Mortality rate and oral health - a cohort study over 44 years in the county of Stockholm.

机构信息

a Department of Periodontology , Public Dental Service at Eastmaninstitutet, Stockholm County Council , Stockholm , Sweden.

b Division of Periodontology, Department of Dental Medicine , Karolinska Institutet , Huddinge , Sweden.

出版信息

Acta Odontol Scand. 2018 May;76(4):299-304. doi: 10.1080/00016357.2018.1423576. Epub 2018 Jan 11.

Abstract

OBJECTIVE

To study the association between oral health and all-cause mortality rate over 44 years. In addition, the specific relations between oral health and death caused by cardiovascular disease (CVD), cancer or other reasons were investigated.

MATERIALS AND METHODS

An epidemiological investigation studying the oral health of the population consisting of 1393 randomly selected subjects was performed in the County of Stockholm. The individuals were invited to a clinical examination, an interview and a radiographic examination. The incidence of mortality during the years 1970-2014 as well as the causes of death according to the death certificate were registered in 2015. Cox regression survival analysis was used for investigating the effect of several variables upon the time to the outcome of death.

RESULTS

Forty-six percent of the subjects were still alive at the end of the year 2014. Cancers caused 27% of the deaths, while 22% died due to CVD. The mortality risk was positively and significantly correlated to oral health when compensated for age, sex, smoking and social status. In addition, the mortality risk caused by CVD, cancer or other reasons was significantly increased for those with poor oral health.

CONCLUSIONS

Oral health was found to be a risk indicator of death caused by CVD and cancer as well as for all-cause mortality. Thus, the associations are unspecific. Harmful lifestyle factors impact dental health behavior as well as mortality risk. This might contribute to the association between oral health and mortality risk.

摘要

目的

研究 44 年来口腔健康与全因死亡率之间的关系。此外,还研究了口腔健康与心血管疾病(CVD)、癌症或其他原因导致的死亡之间的具体关系。

材料和方法

在斯德哥尔摩县进行了一项针对人口口腔健康的流行病学调查,该调查由 1393 名随机选择的受试者组成。邀请这些个体参加临床检查、访谈和影像学检查。2015 年登记了 1970 年至 2014 年期间的死亡率以及根据死亡证明的死因。使用 Cox 回归生存分析来研究几个变量对死亡结果时间的影响。

结果

46%的受试者在 2014 年底仍存活。癌症导致 27%的死亡,而 22%的死亡归因于 CVD。在考虑年龄、性别、吸烟和社会地位后,口腔健康与死亡率的风险呈正相关且具有统计学意义。此外,口腔健康状况差的人因 CVD、癌症或其他原因导致的死亡率显著增加。

结论

口腔健康是 CVD 和癌症导致的死亡以及全因死亡率的危险因素。因此,这种关联是特异性的。不良的生活方式因素会影响口腔健康行为以及死亡率风险。这可能是口腔健康与死亡率风险之间关联的原因。

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