Yamamoto M, Morita K, Waseda Y, Ueno T, Maeda H
Department of Neuropsychiatry, Kurume University School of Medicine, 67 Asahi-machi, Kurume-city, Fukuoka 830, Japan.
Psychiatry Clin Neurosci. 2001 Aug;55(4):347-52. doi: 10.1046/j.1440-1819.2001.00874.x.
The auditory P300 is affected by arousal and emotion. We examined the effect of drawings expressing sadness or pleasure on auditory event-related potentials (ERP) during recovery from schizophrenia. Oddball-paradigm auditory ERP were recorded while presenting one of these drawings to nine patients with paranoid schizophrenia and seven patients with other types of schizophrenia during the acute stage and again during remission. P300 parameters (amplitude, area, and latency), reaction time, and symptom scores were evaluated. P300 amplitude and area were significantly greater in the recovery than in the acute phase. Increases were larger when viewing drawings that expressed sadness than when viewing drawings that expressed pleasure. In paranoid-type patients, P300 when viewing pleasurable drawings was similar to that when viewing sad drawings during the acute phase; in remission, P300 was significantly larger when viewing sad drawings than when viewing pleasurable drawings. In non-paranoid patients, P300 while viewing pleasurable drawings was significantly larger than that while viewing sad drawings during the acute phase; this difference disappeared during recovery. P300 latency and reaction time were not influenced by facial-affect stimuli or recovery. A significant negative correlation was noted between amplitude and negative symptom scores. P300 amplitude and area may be useful state markers during recovery in schizophrenic patients. Effects involving attention resources and emotional arousal are also involved.
听觉P300受觉醒和情绪的影响。我们研究了表达悲伤或愉悦的图画对精神分裂症康复期听觉事件相关电位（ERP）的影响。在向9例偏执型精神分裂症患者和7例其他类型精神分裂症患者的急性期及缓解期分别呈现其中一幅图画时，记录了Oddball范式听觉ERP。评估了P300参数（波幅、面积和潜伏期）、反应时间及症状评分。康复期的P300波幅和面积显著大于急性期。观看表达悲伤的图画时的增幅大于观看表达愉悦的图画时。在偏执型患者中，急性期观看愉悦图画时的P300与观看悲伤图画时相似；缓解期，观看悲伤图画时的P300显著大于观看愉悦图画时。在非偏执型患者中，急性期观看愉悦图画时的P300显著大于观看悲伤图画时；这种差异在康复期消失。P300潜伏期和反应时间不受面部表情刺激或康复的影响。波幅与阴性症状评分之间存在显著负相关。P300波幅和面积可能是精神分裂症患者康复期有用的状态标志物。其中还涉及到注意力资源和情绪觉醒的影响。
