结核病和实验性内毒素血症期间尿激酶型纤溶酶原激活物受体和CD11b的同时上调
Concurrent upregulation of urokinase plasminogen activator receptor and CD11b during tuberculosis and experimental endotoxemia.
作者信息
Juffermans N P, Dekkers P E, Verbon A, Speelman P, van Deventer S J, van der Poll T
机构信息
Laboratory of Experimental Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
出版信息
Infect Immun. 2001 Aug;69(8):5182-5. doi: 10.1128/IAI.69.8.5182-5185.2001.
Abstract
Patients with tuberculosis had higher expression of monocyte urokinase receptor (uPAR) and CD11b than controls. In vitro, lipoarabinomannan and lipopolysaccharide (LPS) from Escherichia coli shared the ability to enhance uPAR and CD11b expression on monocytes and granulocytes. In healthy volunteers, LPS induced increases in monocyte and granulocyte uPAR and CD11b.
摘要
肺结核患者单核细胞尿激酶受体（uPAR）和CD11b的表达高于对照组。在体外，来自大肠杆菌的脂阿拉伯甘露聚糖和脂多糖（LPS）具有共同的能力，可增强单核细胞和粒细胞上uPAR和CD11b的表达。在健康志愿者中，LPS可诱导单核细胞和粒细胞uPAR及CD11b增加。
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