Moulder J E, Fischer J J, Casey A
Radiology. 1975 May;115(2):465-70. doi: 10.1148/115.2.465.
The effects of fractionated irradiation on the feet of rats were the subjects of a time-dose study. The doses required to produce various levels of early skin damage, late skin damage, and late structural damage were determined for single doses and for treatments employing three fractions per week and lasting up to 50 days. The data did not follow the relationship first proposed by strandqvist, in which dose is proportional to time-n; rather, when the normal-tissue reactions were plotted on a linear-coordinate graph, they formed parallel time-dose isoeffect curves with distinct positive curvatures.
分次照射对大鼠足部的影响是一项时间 - 剂量研究的主题。确定了产生不同程度早期皮肤损伤、晚期皮肤损伤和晚期结构损伤所需的单剂量以及每周三次、持续长达50天的治疗剂量。数据并不遵循斯特兰德奎斯特最初提出的剂量与时间 - n成正比的关系；相反，当将正常组织反应绘制在直角坐标图上时，它们形成了具有明显正曲率的平行时间 - 剂量等效效应曲线。
