Moulder J E, Lo P S, Fischer J J
Br J Cancer Suppl. 1978 Jun;3:216-9.
A combination of the radiosensitizer, metronidazole, and the radioprotector, dimethyl sulfoxide (DMSO), was tested for its effects on the radiation tolerance of rat skin and on the radiosensitivity of the BA1112 rhabdomyosarcoma. The simplest interpretation of the effects of the combined treatment is that: metronidazole radiosensitizes BA1112 in one-fraction but not in five-fraction treatments; metronidazole slightly increases the radiosensitivity of skin in one-fraction treatments; metronidazole radiosensitization is independent of the radioprotection produced by DMSO.
对放射增敏剂甲硝唑和放射防护剂二甲基亚砜（DMSO）的组合进行了测试，以考察其对大鼠皮肤辐射耐受性以及BA1112横纹肌肉瘤放射敏感性的影响。联合治疗效果的最简单解释是：甲硝唑在单次照射治疗中可使BA1112增敏，但在分次照射治疗中则不然；甲硝唑在单次照射治疗中可轻微提高皮肤的放射敏感性；甲硝唑的放射增敏作用与DMSO产生的放射防护作用无关。
