van Rongen E, Kal H B
Radiother Oncol. 1984 Aug;2(2):141-50. doi: 10.1016/s0167-8140(84)80050-x.
Acute reactions of rat foot skin to regimens of X-irradiation involving single and multiple fractions per day were determined. The influence of an interval halfway through the treatment course was investigated for a multiple fractions per day regimen. The regimen was one in which 4 fractions of 2 Gy were given each day. Two courses of up to the tolerance dose separated by an interval of several weeks can be given without causing excessive skin damage. Repopulation during the interval was found to be responsible for the increase in tolerance. Repopulation started at about 2 weeks after the beginning of treatment. Using Barendsen's isoeffect model [4], doses which when given daily would result in the same biological effect as 4 X 2 Gy given daily, were calculated. Rat feet were irradiated with these doses. It was concluded that the isoeffect model provides good predictions of the tolerance doses in new irradiation regimens for the acute reaction of the rat foot skin.
测定了大鼠足部皮肤对每天单次和多次X射线照射方案的急性反应。对于每天多次照射方案，研究了治疗过程中间隔的影响。该方案是每天给予4次2 Gy的照射。可以给予两个疗程，直至耐受剂量，中间间隔数周，而不会造成过度的皮肤损伤。发现间隔期间的再增殖是耐受性增加的原因。再增殖在治疗开始后约2周开始。使用巴伦德森等效效应模型[4]，计算出每天给予时与每天给予4×2 Gy产生相同生物学效应的剂量。用这些剂量对大鼠足部进行照射。得出的结论是，等效效应模型能很好地预测大鼠足部皮肤急性反应新照射方案中的耐受剂量。
