Randers-Pehrson G, Geard C R, Johnson G, Elliston C D, Brenner D J
Center for Radiological Research, Radiological Research Accelerator Facility, Columbia University, Irvington, New York 10533, USA.
Radiat Res. 2001 Aug;156(2):210-4. doi: 10.1667/0033-7587(2001)156[0210:tcusim]2.0.co;2.
A single-ion microbeam facility has been constructed at the Columbia University Radiological Research Accelerator Facility. The system was designed to deliver defined numbers of helium or hydrogen ions produced by a van de Graaff accelerator, covering a range of LET from 30 to 220 keV/microm, into an area smaller than the nuclei of human cells growing in culture on thin plastic films. The beam is collimated by a pair of laser-drilled apertures that form the beam-line exit. An integrated computer control program locates the cells and positions them for irradiation. We present details of the microbeam facility including descriptions of the collimators, hardware, control program, and the various protocols available. Various contributions to targeting and positioning precision are discussed along with our plans for future developments. Beam time for outside users is often available (see www.raraf.org).
哥伦比亚大学放射研究加速器设施已建成一个单离子微束装置。该系统旨在将范德格拉夫加速器产生的特定数量的氦离子或氢离子输送到比在薄塑料薄膜上培养的人类细胞核还小的区域，其线能量转移（LET）范围为30至220 keV/微米。束流通过一对形成束流线出口的激光钻孔孔径进行准直。一个集成的计算机控制程序定位细胞并将其定位以便进行辐照。我们介绍了微束装置的详细情况，包括准直器、硬件、控制程序以及可用的各种方案的描述。讨论了对靶向和定位精度的各种贡献以及我们未来的发展计划。外部用户通常可以使用束流时间（见www.raraf.org）。
