Gail D B, Massaro G D, Massaro D
Respir Physiol. 1975 Mar;23(2):175-80. doi: 10.1016/0034-5687(75)90058-4.
The authors used waltzing and nonwaltzing mice to examine granular pneumocyte mitochondria and lung oxygen consumption and protein synthesis. They found that the oxygen consumption of lung slices from waltzing mice is higher than that of lung slices from nonwaltzing mice. The volume density of granular pneumocyte mitochondria is higher in waltzing than nonwaltzing mice as is their number per 100 mum-3 of cytoplasm. The mean, length, width, volume and surface density of individual mitochondria are the same in both groups. The incorporation of [14-C]leucine by lung slices into protein in a surface active lung fraction is greater in lung slices from waltzing than nonwaltzing mice. This difference occurs in the face of similar levels of free leucine in both groups. The authors conclude that there are intraspecies differences in lung oxygen consumption and protein synthesis and in the volume density and number of granular pneumocyte mitochondria.
作者使用华尔兹小鼠和非华尔兹小鼠来研究颗粒状肺细胞线粒体以及肺的氧消耗和蛋白质合成。他们发现，华尔兹小鼠肺切片的氧消耗高于非华尔兹小鼠肺切片。华尔兹小鼠颗粒状肺细胞线粒体的体积密度高于非华尔兹小鼠，每100μm³细胞质中的线粒体数量也是如此。两组中单个线粒体的平均长度、宽度、体积和表面密度相同。在表面活性肺组分中，华尔兹小鼠肺切片将[14-C]亮氨酸掺入蛋白质的量比非华尔兹小鼠肺切片更多。尽管两组中游离亮氨酸水平相似，但仍存在这种差异。作者得出结论，在肺氧消耗、蛋白质合成以及颗粒状肺细胞线粒体的体积密度和数量方面存在种内差异。
