Helbig H, Sutter F, Thölen A
Klinik für Augenkrankheiten, Kantonsspital St. Gallen, 9007 St. Gallen, Schweiz.
Ophthalmologe. 2001 Jun;98(6):574-8. doi: 10.1007/s003470170122.
The "white dot syndromes" are a clinically heterogeneous group of inflammatory chorioretinopathies with an inconsistent classification. It is not yet clear if they represent distinct entities or if they are only different forms of the same basic disease.
A 53-year-old female patient presented with unilateral photopsia and reduced vision in the left eye. Funduscopy of the left eye showed peripapillary confluent whitish infiltrates in the deep retinal layers with corresponding enlargement of the blind spot. Slow progression of the lesions was observed followed by the development of subretinal fibrosis in the macula. The ERG was reduced in the left eye. In both eyes there were small round, partly confluent areas of RPE atrophy in the lower fundus periphery without inflammatory reaction in the vitreous body or anterior chamber.
The presented case shows overlapping features of acute zonal occult outer retinopathy (AZOOR), multifocal choroiditis and diffuse subretinal fibrosis and uveitis. This case and other previously described cases with overlaps between different clinical entities support the theory that clinically different inflammatory chorioretinal diseases may represent parts of a spectrum of one common disease.
“白点综合征”是一组临床异质性的炎症性脉络膜视网膜病变，分类并不一致。目前尚不清楚它们是代表不同的实体，还是仅仅是同一种基础疾病的不同形式。
一名53岁女性患者出现左眼单眼闪光感及视力下降。左眼眼底检查显示视乳头周围深层视网膜层有融合性白色浸润，盲点相应扩大。观察到病变进展缓慢，随后黄斑区出现视网膜下纤维化。左眼视网膜电图降低。双眼眼底下方周边有小的圆形、部分融合的视网膜色素上皮萎缩区，玻璃体或前房无炎症反应。
该病例显示出急性区域性隐匿性外层视网膜病变（AZOOR）、多灶性脉络膜炎以及弥漫性视网膜下纤维化和葡萄膜炎的重叠特征。该病例以及其他先前描述的不同临床实体之间存在重叠的病例支持了这样一种理论，即临床上不同的炎症性脉络膜视网膜疾病可能是一种常见疾病谱的一部分。
