大肠杆菌DNA促旋酶gyrA基因中的喹诺酮耐药决定区。
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.
作者信息
Yoshida H, Bogaki M, Nakamura M, Nakamura S
机构信息
Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Osaka, Japan.
出版信息
Antimicrob Agents Chemother. 1990 Jun;34(6):1271-2. doi: 10.1128/AAC.34.6.1271.
Abstract
Nucleotide sequence analysis of the gyrA genes of 10 spontaneous quinolone-resistant gyrA mutants of Escherichia coli KL16, including four mutants examined previously, disclosed that quinolone resistance was caused by a point mutation within the region between amino acids 67 and 106, especially in the vicinity of amino acid 83, of the GyrA protein.
摘要
对10株大肠杆菌KL16喹诺酮耐药性自发gyrA突变体（包括之前检测的4个突变体）的gyrA基因进行核苷酸序列分析，结果表明，喹诺酮耐药性是由GyrA蛋白67至106位氨基酸区域内的点突变引起的，尤其是在83位氨基酸附近。
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