Carlson G R, Dhadialla T S, Hunter R, Jansson R K, Jany C S, Lidert Z, Slawecki R A
Rohm and Haas Research Laboratories, 727 Norristown Road, Spring House, PA 19477, USA.
Pest Manag Sci. 2001 Feb;57(2):115-9. doi: 10.1002/1526-4998(200102)57:2<115::AID-PS245>3.0.CO;2-A.
Methoxyfenozide [N-tert-butyl-N'-(3-methoxy-o-toluoyl)-3,5-xylohydrazide; RH-2485] is the newest diacylhydrazine insecticide to reach the marketplace. It binds with very high affinity to the ecdysone receptor complex (EcR:USP) in lepidopteran insects [Kd = 0.5 nM (Plodia)], where it functions as a potent agonist, or mimic, of the insect molting hormone, 20-hydroxyecdysone (20E). Methoxyfenozide exhibits high insecticidal efficacy against a wide range of important caterpillar pests, including many members of the family Pyralidae, Pieridae, Tortricidae and Noctuidae. It is most effective when ingested by the target caterpillar, but it also has some topical and ovicidal properties. It is modestly root systemic, but not significantly leaf-systemic. Evidence collected to date indicates that methoxyfenozide has an excellent margin of safety to non-target organisms, including a wide range of non-target and beneficial insects.
甲氧虫酰肼[N-叔丁基-N'-(3-甲氧基-邻甲苯甲酰基)-3,5-二甲苯酰肼；RH-2485]是最新进入市场的双酰肼类杀虫剂。它以极高的亲和力与鳞翅目昆虫中的蜕皮激素受体复合物（EcR:USP）结合[解离常数Kd = 0.5 nM（印度谷螟）]，在其中它作为昆虫蜕皮激素20-羟基蜕皮酮（20E）的强效激动剂或模拟物发挥作用。甲氧虫酰肼对多种重要的毛虫害虫具有高杀虫活性，包括螟蛾科、粉蝶科、卷蛾科和夜蛾科的许多成员。当被目标毛虫摄入时它最为有效，但它也具有一些触杀和杀卵特性。它有一定的根部内吸性，但叶部内吸性不显著。迄今为止收集的证据表明，甲氧虫酰肼对非靶标生物具有出色的安全边际，包括多种非靶标和有益昆虫。
