Combination treatment in autoimmune diseases. Methodology of combination trials.
作者信息
Boers M
机构信息
Department of Clinical Epidemiology & Biostatistics, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.
出版信息
Springer Semin Immunopathol. 2001;23(1-2):27-33. doi: 10.1007/s002810100073.
PMID:11455857
Abstract
Even with the limited number of antirheumatic agents available, theoretical considerations lead to an almost infinite number of combination strategies. This article outlines possible strategies based on the primary choice between maximization of efficacy or minimization of toxicity. Strategies are illustrated with examples from trial experience in the field of rheumatoid arthritis.
摘要
Zotero 插件