1-O-没食子酰基-6-O-（4-羟基-3,5-二甲氧基）苯甲酰基-β-D-葡萄糖，一种来自四角风车子的新型保肝成分。
1-O-galloyl-6-O-(4-hydroxy-3,5-dimethoxy)benzoyl-beta-D-glucose, a new hepatoprotective constituent from Combretum quadrangulare.
作者信息
Adnyana I K, Tezuka Y, Awale S, Banskota A H, Tran K Q, Kadota S
出版信息
Planta Med. 2001 Jun;67(4):370-1. doi: 10.1055/s-2001-14318.
PMID:11458461
Abstract
A new gallic acid derivative, 1-O-galloyl-6-O-(4-hydroxy-3,5-dimethoxy)benzoyl-beta-D-glucose (1) has been isolated from an H2O-fraction of MeOH extract of Combretum quadrangulare seeds. Compound 1 exhibited potent hepatoprotective activity against D-GalN/TNF-alpha-induced cell death in primary cultured mouse hepatocytes with an IC50 of 3.3 microM.
摘要
一种新的没食子酸衍生物，1-O-没食子酰基-6-O-(4-羟基-3,5-二甲氧基)苯甲酰基-β-D-葡萄糖(1)已从四角风车子种子甲醇提取物的水部分中分离出来。化合物1对原代培养的小鼠肝细胞中D-半乳糖胺/肿瘤坏死因子-α诱导的细胞死亡表现出强大的肝保护活性，半数抑制浓度为3.3微摩尔/升。
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