Adnyana I K, Tezuka Y, Banskota A H, Tran K Q, Kadota S
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630-Sugitani, Toyama 930-0194, Japan.
J Nat Prod. 2001 Mar;64(3):360-3. doi: 10.1021/np000486x.
Three new triterpenes of the lupane type, 2alpha,6beta-dihydroxybetulinic acid (1) and 6beta-hydroxyhovenic acid (2), and an oleanane type, 6beta-hydroxyarjunic acid (3), together with several known compounds, have been isolated from the MeOH extract of the seeds of Combretum quadrangulare. The structures of these compounds were elucidated on the basis of spectroscopic analysis, and their hepatoprotective activities were tested for D-GalN/TNF-alpha-induced cell death in primary cultured mouse hepatocytes.
从四角风车子种子的甲醇提取物中分离出了三种新的羽扇豆烷型三萜化合物，即2α,6β - 二羟基桦木酸（1）和6β - 羟基蛇麻脂酸（2），以及一种齐墩果烷型化合物6β - 羟基阿尔朱尼酸（3），还有几种已知化合物。通过光谱分析阐明了这些化合物的结构，并在原代培养的小鼠肝细胞中测试了它们对D - 半乳糖胺/肿瘤坏死因子 - α诱导的细胞死亡的肝保护活性。
