Kesler S R, Hopkins R O, Weaver L K, Blatter D D, Edge-Booth H, Bigler E D
Psychology Department, Brigham Young University, Provo, Utah 84602, USA.
J Int Neuropsychol Soc. 2001 Jul;7(5):640-6. doi: 10.1017/s1355617701005112.
Magnetic resonance (MR) images and neuropsychological testing data of 69 carbon monoxide (CO) poisoned patients were prospectively obtained within 1 day of CO poisoning, two weeks and six months. CO patients' Day 1 cross-sectional fornix surface area measurements, corrected for head size by using a fornix-to-brain ratio (FBR), were compared to normal age and gender-matched controls. Additionally, a within-subjects analysis was performed comparing the mean areas between CO patients' Day 1, 2 weeks and 6-month FBR. The FBR was correlated with patients' neuropsychological data. There were no significant differences between CO patients' Day 1 fornix measurements compared to normal control subjects. However, significant atrophic changes in the fornix of CO poisoned patients occurred at two weeks with no progressive atrophy at 6 months. By 6 months, CO patients showed significant decline on tests of verbal memory (when practice effects were taken into account), whereas visual memory, processing speed and attention/concentration did not decline. This study indicates that CO results in brain damage and cognitive impairments in the absence of lesions and other neuroanatomic markers.
前瞻性地获取了69名一氧化碳（CO）中毒患者在CO中毒后1天、两周和六个月时的磁共振（MR）图像及神经心理学测试数据。通过使用穹窿与脑比例（FBR）对头部大小进行校正后，将CO患者第1天的横断面穹窿表面积测量结果与年龄和性别匹配的正常对照组进行比较。此外，还进行了一项受试者内分析，比较了CO患者第1天、两周和六个月时FBR的平均面积。FBR与患者的神经心理学数据相关。与正常对照组相比，CO患者第1天的穹窿测量结果无显著差异。然而，CO中毒患者的穹窿在两周时出现了明显的萎缩变化，六个月时无进行性萎缩。到六个月时，CO患者在言语记忆测试中表现出显著下降（考虑到练习效应），而视觉记忆、处理速度和注意力/专注力并未下降。这项研究表明，在没有病变和其他神经解剖学标志物的情况下，CO会导致脑损伤和认知障碍。
