Novel piperidinyloxy oxazolidinone antimicrobial agents.
作者信息
Weidner-Wells M A, Boggs C M, Foleno B D, Wira E, Bush K, Goldschmidt R M, Hlasta D J
机构信息
Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202, 08869, Raritan, NJ, USA.
出版信息
Bioorg Med Chem Lett. 2001 Jul 23;11(14):1829-32. doi: 10.1016/s0960-894x(01)00305-5.
Abstract
Oxazolidinone antibacterial agents, where the N-substituted piperazinyl group of eperezolid was replaced with a N-substituted piperidinyloxy moiety, were synthesized and shown to be active against a variety of resistant and susceptible Gram-positive organisms. The effect of ring size, positional isomerism, and fluorine substitution on antibacterial activity was examined.
摘要
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