具有环状磺酰胺部分的新型恶唑烷酮的合成及其抗菌活性
Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties.
作者信息
Kim Seong Jong, Jung Myung-Ho, Yoo Kyung Ho, Cho Jung-Hyuck, Oh Chang-Hyun
机构信息
Life Sciences Research Division, Korea Institute of Science and Technology, Cheongryang, Seoul 130-650, Republic of Korea.
出版信息
Bioorg Med Chem Lett. 2008 Nov 1;18(21):5815-8. doi: 10.1016/j.bmcl.2008.09.034. Epub 2008 Sep 11.
The synthesis of a new series of oxazolidinones having cyclic sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the oxazolidinone ring was investigated. A particular compound 15g having [1,2,5]thiadiazolidin-1,1-dioxide moiety showed the most potent antibacterial activity.
描述了一系列具有环状磺酰胺部分的新型恶唑烷酮的合成。测试了它们对革兰氏阳性菌和革兰氏阴性菌的体外抗菌活性，并研究了取代基对恶唑烷酮环的影响。一种具有[1,2,5]噻二唑烷-1,1-二氧化物部分的特定化合物15g表现出最强的抗菌活性。
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