脊椎动物细胞中的同源DNA重组。
Homologous DNA recombination in vertebrate cells.
作者信息
Sonoda E, Takata M, Yamashita Y M, Morrison C, Takeda S
机构信息
Department of Radiation Genetics, Faculty of Medicine, Kyoto University, Yoshida Konoe, Sakyo-ku, Kyoto 606-8501, Japan.
出版信息
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8388-94. doi: 10.1073/pnas.111006398.
Abstract
The RAD52 epistasis group genes are involved in homologous DNA recombination, and their primary structures are conserved from yeast to humans. Although biochemical studies have suggested that the fundamental mechanism of homologous DNA recombination is conserved from yeast to mammals, recent studies of vertebrate cells deficient in genes of the RAD52 epistasis group reveal that the role of each protein is not necessarily the same as that of the corresponding yeast gene product. This review addresses the roles and mechanisms of homologous recombination-mediated repair with a special emphasis on differences between yeast and vertebrate cells.
摘要
RAD52上位性组基因参与同源DNA重组，其一级结构从酵母到人类都保守。尽管生化研究表明同源DNA重组的基本机制从酵母到哺乳动物都是保守的，但最近对RAD52上位性组基因缺陷的脊椎动物细胞的研究表明，每种蛋白质的作用不一定与相应酵母基因产物的作用相同。本综述探讨同源重组介导的修复的作用和机制，特别强调酵母和脊椎动物细胞之间的差异。
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