加拿大女性单纯疱疹病毒2型（HSV-2）的产前血清流行率：HSV-2流行率在整个生育年龄期间呈上升趋势。
Antenatal seroprevalence of herpes simplex virus type 2 (HSV-2) in Canadian women: HSV-2 prevalence increases throughout the reproductive years.
作者信息
Patrick D M, Dawar M, Cook D A, Krajden M, Ng H C, Rekart M L
机构信息
University of British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada.
出版信息
Sex Transm Dis. 2001 Jul;28(7):424-8. doi: 10.1097/00007435-200107000-00011.
BACKGROUND
This study sought to provide the first population estimates of herpes simplex type 2 (HSV-2) seroprevalence in Canada.
GOAL
To measure the antenatal seroprevalence of HSV-2 antibodies in reproductive age women.
STUDY DESIGN
An anonymous unlinked seroprevalence study used stored sera collected from pregnant women in British Columbia during 1999. Randomized sampling within age strata selected a total of 1215 subjects, ages 15 to 44 years. Serologic testing used the Gull Meridian Test. Overall prevalence was directly standardized to the 1999 Canadian female population.
RESULTS
The age-adjusted prevalence for HSV-2 was 17.3% (95% CI, 15.2-19.4). Prevalence ranged from 7.1% (ages, 15-19 years) to 28.1% (ages, 40-44 years), with the largest increases after the age of 24 years.
CONCLUSIONS
The HSV-2 seroprevalence among pregnant women in British Columbia is similar to that in the United States and other countries. Seroprevalence continues to rise through the later reproductive years. This observation may relate to continued transmission, an age cohort effect, or both.
背景
本研究旨在提供加拿大单纯疱疹病毒2型（HSV-2）血清流行率的首批人群估计值。
目标
测量育龄妇女中HSV-2抗体的产前血清流行率。
研究设计
一项匿名非关联血清流行率研究，使用了1999年从不列颠哥伦比亚省孕妇中收集的储存血清。在年龄层内进行随机抽样，共选取了1215名年龄在15至44岁之间的受试者。血清学检测使用Gull Meridian检测法。总体流行率直接标准化为1999年加拿大女性人口的流行率。
结果
HSV-2的年龄调整后流行率为17.3%（95%置信区间，15.2 - 19.4）。流行率范围从7.1%（15至19岁年龄组）到28.1%（40至44岁年龄组），24岁以后增长幅度最大。
结论
不列颠哥伦比亚省孕妇中的HSV-2血清流行率与美国及其他国家相似。血清流行率在生育后期持续上升。这一观察结果可能与持续传播、年龄队列效应或两者都有关。
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