荷兰孕妇中1型和2型单纯疱疹病毒的血清流行率。
Seroprevalences of herpes simplex virus type 1 and type 2 among pregnant women in the Netherlands.
作者信息
Gaytant Michael A, Steegers Eric A P, van Laere Marloes, Semmekrot Ben A, Groen Jan, Weel Jan F, van der Meijden Willem I, Boer Kees, Galama Jochem M D
机构信息
Department of Obstetrics and Gynecology, Virology Section, University Medical Center, Nijmegen, The Netherlands.
出版信息
Sex Transm Dis. 2002 Nov;29(11):710-4. doi: 10.1097/00007435-200211000-00015.
BACKGROUND
In the Netherlands 73% of cases of neonatal herpes are caused by herpes simplex virus type 1 (HSV-1), whereas in the United States a majority are caused by HSV type 2 (HSV-2). GOAL To understand this difference we undertook a seroepidemiological study on the prevalence of HSV-1 and HSV-2 among pregnant women.
STUDY DESIGN
Type-specific antibodies to HSV-1 and HSV-2 were detected by enzyme-linked immunosorbent assay (ELISA) in serum samples from 1,507 pregnant women in Amsterdam, Rotterdam, and Nijmegen.
RESULTS
The prevalence of HSV-1 was 61% in Nijmegen, 73% in Amsterdam, and 75% in Rotterdam. The prevalence of HSV-2 was 11% in Nijmegen, 35% in Amsterdam, and 27% in Rotterdam.
CONCLUSION
The seroprevalence of HSV-1 and HSV-2 antibodies among pregnant women in the Netherlands shows significant geographical differences, which were attributed to ethnical variation. However, the epidemiologic differences did not correlate with the incidence of neonatal herpes in the Netherlands.
背景
在荷兰，73%的新生儿疱疹病例由1型单纯疱疹病毒（HSV-1）引起，而在美国，大多数病例由2型单纯疱疹病毒（HSV-2）引起。目的：为了解这种差异，我们对孕妇中HSV-1和HSV-2的流行情况进行了血清流行病学研究。
研究设计
采用酶联免疫吸附测定（ELISA）检测了来自阿姆斯特丹、鹿特丹和奈梅亨的1507名孕妇血清样本中针对HSV-1和HSV-2的型特异性抗体。
结果
HSV-1的流行率在奈梅亨为61%，在阿姆斯特丹为73%，在鹿特丹为75%。HSV-2的流行率在奈梅亨为11%，在阿姆斯特丹为35%，在鹿特丹为27%。
结论
荷兰孕妇中HSV-1和HSV-2抗体的血清流行率存在显著的地理差异，这归因于种族差异。然而，这些流行病学差异与荷兰新生儿疱疹的发病率并无关联。
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