Malekzadeh F, Ehsanifar H, Shahamat M, Levin M, Colwell R R
Department of Microbiology and Biological Sciences, University of Tehran, Tehran, Iran.
Int J Antimicrob Agents. 2001 Jul;18(1):85-8. doi: 10.1016/s0924-8579(01)00352-1.
The effect of ether, alcoholic and water extracts of black myrobalan (Teminalia chebula Retz) on Helicobactor pylori were examined using an agar diffusion method on Columbia Agar. Water extracts of black myrobalan showed significant antibacterial activity and had a minimum inhibitory concentration (MIC) and minimum bacteriocidal concentration (MBC) of 125 and 150 mg/l, respectively. The extract was active after autoclaving for 30 min at 121 degrees C. Plant powder (incorporated in agar) gave higher MIC and MBC values (150 and 175 mg/l, respectively). Water extracts of the black myrobalan at a concentration of 1-2.5 mg/ml inhibited urease activity of H. pylori. The results show that black myrobalan extracts contain a heat stable agent(s) with possible therapeutic potential. Other bacterial species were also inhibited by black myrobalan water extracts.
采用琼脂扩散法，在哥伦比亚琼脂上检测了诃子（Terminalia chebula Retz）的乙醚提取物、乙醇提取物和水提取物对幽门螺杆菌的作用。诃子水提取物表现出显著的抗菌活性，其最低抑菌浓度（MIC）和最低杀菌浓度（MBC）分别为125mg/l和150mg/l。该提取物在121℃高压灭菌30分钟后仍具有活性。植物粉末（加入琼脂中）的MIC和MBC值更高（分别为150mg/l和175mg/l）。浓度为1 - 2.5mg/ml的诃子水提取物可抑制幽门螺杆菌的尿素酶活性。结果表明，诃子提取物含有一种热稳定剂，可能具有治疗潜力。诃子水提取物对其他细菌种类也有抑制作用。
