Enebish Gerelmaa, Song Wang, Xi Wei Cheng, Gantumur Anuujin, Altanbayar Oyunbaatar, Shimomura Hirofumi, Chimeddorj Battogtokh, Chuluun Batnairamdal, Amgalanbaatar Avarzed
Department of Microbiology and Infection Prevention Control, School of Biomedicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.
Affiliated Hospital of Inner Mongolia Minzu University, Tongliao, Inner Mongolia, China.
J Pharmacopuncture. 2023 Mar 31;26(1):18-26. doi: 10.3831/KPI.2023.26.1.18.
, the main ingredient of Altan Arur 5, has been used for many years in traditional medicine. This medicine is more effective than other drugs and is used to treat chronic gastritis and gastrointestinal disorders such as peptic ulcers and esophageal reflux. Other ingredients of Altan Arur 5 are (pomegranate), tulip seeds, black balm, and excreta of . The main ingredients of are antibacterial and analgesic in traditional medicine. Despite having been used for many years and although many studies have been conducted on the beneficial effects of this medicine and its ingredients, the toxicity of Altan Arur 5 has not yet been elucidated. Therefore, we aimed to study the toxicity of Altan Arur 5 to ensure that it is safe to use.
Acute and chronic toxicity of Altan Arur 5 were assessed in 10 Kunming mice and 8 Sprague-Dawley rats, respectively, in different doses. In the acute toxicity study, Altan Arur 5 was orally administered to Kunming mice in doses of 12 g/kg, 24 g/kg, and 48 g/kg for 14 days. In the chronic toxicity study, it was orally administered to Sprague-Dawley rats in doses of 1.25 g/kg, 2.5 g/kg, and 5 g/kg for 12 weeks.
No significant differences were observed in the relative organ weights for mice treated with Altan Arur 5 compared with those in the control group. Furthermore, no macro- or microstructural changes were noted in the organs of any group.
Our toxicity testing revealed that the traditional medicine Altan Arur 5 has no toxic effects in vivo.
阿尔坦阿鲁尔5（Altan Arur 5）的主要成分，已在传统医学中使用多年。这种药物比其他药物更有效，用于治疗慢性胃炎和胃肠道疾病，如消化性溃疡和食管反流。阿尔坦阿鲁尔5的其他成分有石榴、郁金香种子、黑香脂和麝鼹排泄物。在传统医学中，其主要成分具有抗菌和止痛作用。尽管已使用多年，并且对这种药物及其成分的有益效果进行了许多研究，但阿尔坦阿鲁尔5的毒性尚未阐明。因此，我们旨在研究阿尔坦阿鲁尔5的毒性，以确保其使用安全。
分别以不同剂量对10只昆明小鼠和8只斯普拉格-道利大鼠评估阿尔坦阿鲁尔5的急性和慢性毒性。在急性毒性研究中，以12 g/kg、24 g/kg和48 g/kg的剂量给昆明小鼠口服阿尔坦阿鲁尔5，持续14天。在慢性毒性研究中，以1.25 g/kg、2.5 g/kg和5 g/kg的剂量给斯普拉格-道利大鼠口服，持续12周。
与对照组相比，用阿尔坦阿鲁尔5处理的小鼠的相对器官重量没有观察到显著差异。此外，任何组的器官均未发现宏观或微观结构变化。
我们的毒性测试表明，传统药物阿尔坦阿鲁尔5在体内没有毒性作用。
