Miller L T, Johnson A, Benson E M, Woodring M J
Am J Clin Nutr. 1975 Aug;28(8):846-53. doi: 10.1093/ajcn/28.8.846.
The effect of supplementary pyridoxine on the metabolism of vitamin B6 as well as plasma tryptophan and alpha-amino nitrogen was determined in women using oral contraceptive agents. Ten women who were taking oral contraceptive agents and 11 who had never taken them served as subjects. Blood from the various biochemical measurements was drawn from fasting subjects before and after they had received an oral dose of 50 mg of pyridoxine-HCl daily fo 2 days. The use of oral contraceptive agents had no effect on the levels of blood vitamin B6, plasma pyridoxal phosphate, and plasma tryptophan. The activity of erythrocyte glutamic oxaloacetic transaminase was higher (P less than 0.05) in the oral contraceptive agent users than in the nonusers but the stimulation in vitro by pyridoxal phosphate was similar for the two groups. Plasma alpha-amino nitrogen was slightly lower in the oral contraceptive agent users than in the nonusers, but the difference was not statistically significant. The rise in blood vitamin B6 in response to pyridoxine was similar in the two groups, but the rise in plasma pyridoxal phosphate tended to be lower in the oral contraceptive agent treated subjects. Following pyridoxine supplementation, the basal activity of erythrocyte glutamic oxalocetic transaminase increased (P less than 0.01) in both groups of subjects and the stimulation in vitro by pyridoxal phosphate decreased correspondingly. Plasma tryptophan and alpha-amino nitrogen were unaffected by the supplementary pyridoxine.
研究了补充吡哆醇对口服避孕药女性维生素B6代谢以及血浆色氨酸和α-氨基氮的影响。10名服用口服避孕药的女性和11名从未服用过口服避孕药的女性作为研究对象。在空腹受试者每日口服50毫克盐酸吡哆醇，持续2天前后，采集血液进行各项生化指标检测。口服避孕药的使用对血液维生素B6、血浆磷酸吡哆醛和血浆色氨酸水平没有影响。口服避孕药使用者的红细胞谷草转氨酶活性高于未使用者（P<0.05），但两组在体外受磷酸吡哆醛刺激的情况相似。口服避孕药使用者的血浆α-氨基氮略低于未使用者，但差异无统计学意义。两组对吡哆醇反应的血液维生素B6升高情况相似，但口服避孕药治疗的受试者血浆磷酸吡哆醛的升高趋势较低。补充吡哆醇后，两组受试者红细胞谷草转氨酶的基础活性均增加（P<0.01），且体外受磷酸吡哆醛的刺激相应降低。补充吡哆醇对血浆色氨酸和α-氨基氮没有影响。
