高热量葡萄糖输注对损伤和脓毒症脂质代谢的影响。

Effects of hypercaloric glucose infusion on lipid metabolism in injury and sepsis.

作者信息

Carpentier Y A, Askanazi J, Elwyn D H, Jeevanandam M, Gump F E, Hyman A I, Burr R, Kinney J M

出版信息

J Trauma. 1979 Sep;19(9):649-54. doi: 10.1097/00005373-197909000-00002.

DOI:10.1097/00005373-197909000-00002

PMID:114675

Abstract

UNLABELLED

Lipolysis was studied by measuring glycerol turnover (GTO) in injured and infected patients. GTO was elevated two to three times the normal values in five injured and four infected patients during D5W infusion. No correlation was found between GTO and plasma glycerol concentration in the two patient groups. GTO showed similar levels when measured during TPN in five injured and three infected patients. During TPN, plasma FFA levels remained unchanged in injured but decreased by 48% in septic patients. B-OH butyrate concentrations were high during D5W and dropped in both groups during TPN. Norepinephrine urinary output was high in both groups during D5W and TPN.

CONCLUSIONS

GTO was elevated two to three times the normal range in injury and infection; plasma glycerol concentration was not related to GTO. 2) In face of high catecholamine output, the insulin response to TPN did not inhibit TG breakdown but did decrease plasma ketone body concentrations.

摘要

未标注

通过测量受伤和感染患者的甘油周转率（GTO）来研究脂肪分解。在5名受伤患者和4名感染患者接受5%葡萄糖输注期间，GTO升高至正常值的两到三倍。在这两组患者中，未发现GTO与血浆甘油浓度之间存在相关性。在5名受伤患者和3名感染患者接受全胃肠外营养（TPN）期间测量时，GTO显示出相似水平。在TPN期间，受伤患者的血浆游离脂肪酸（FFA）水平保持不变，但脓毒症患者的血浆FFA水平下降了48%。在5%葡萄糖输注期间，两组患者的β-羟丁酸浓度都很高，而在TPN期间两组患者的β-羟丁酸浓度均下降。在5%葡萄糖输注和TPN期间，两组患者的去甲肾上腺素尿量都很高。