Carpentier Y A, Askanazi J, Elwyn D H, Jeevanandam M, Gump F E, Hyman A I, Burr R, Kinney J M
J Trauma. 1979 Sep;19(9):649-54. doi: 10.1097/00005373-197909000-00002.
Lipolysis was studied by measuring glycerol turnover (GTO) in injured and infected patients. GTO was elevated two to three times the normal values in five injured and four infected patients during D5W infusion. No correlation was found between GTO and plasma glycerol concentration in the two patient groups. GTO showed similar levels when measured during TPN in five injured and three infected patients. During TPN, plasma FFA levels remained unchanged in injured but decreased by 48% in septic patients. B-OH butyrate concentrations were high during D5W and dropped in both groups during TPN. Norepinephrine urinary output was high in both groups during D5W and TPN.
通过测量受伤和感染患者的甘油周转率（GTO）来研究脂肪分解。在5名受伤患者和4名感染患者接受5%葡萄糖输注期间，GTO升高至正常值的两到三倍。在这两组患者中，未发现GTO与血浆甘油浓度之间存在相关性。在5名受伤患者和3名感染患者接受全胃肠外营养（TPN）期间测量时，GTO显示出相似水平。在TPN期间，受伤患者的血浆游离脂肪酸（FFA）水平保持不变，但脓毒症患者的血浆FFA水平下降了48%。在5%葡萄糖输注期间，两组患者的β-羟丁酸浓度都很高，而在TPN期间两组患者的β-羟丁酸浓度均下降。在5%葡萄糖输注和TPN期间，两组患者的去甲肾上腺素尿量都很高。
1）在受伤和感染时，GTO升高至正常范围的两到三倍；血浆甘油浓度与GTO无关。2）面对高儿茶酚胺输出，胰岛素对TPN的反应并未抑制甘油三酯分解，但确实降低了血浆酮体浓度。
