Samra J S, Summers L K, Frayn K N
Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford, UK.
Br J Surg. 1996 Sep;83(9):1186-96. doi: 10.1046/j.1365-2168.1996.02445.x.
Sepsis is a common surgical problem which can induce profound changes in the plasma concentrations of cytokines and hormones, leading to a catabolic state. Hypertriglyceridaemia and increased fat oxidation are the main features of altered fat metabolism encountered in this state. The endogenous catabolism of sepsis can be reduced by administering exogenous lipid emulsions as a source of metabolic fuel, although the changes in lipid metabolism associated with sepsis may affect the handling of these exogenous lipids. An exciting area for future research is an examination of the ability of lipid emulsions to reduce the morbidity and mortality associated with sepsis by altering immune responses, in addition to limiting catabolism.
脓毒症是一个常见的外科问题，它可引起细胞因子和激素血浆浓度的深刻变化，导致分解代谢状态。高甘油三酯血症和脂肪氧化增加是这种状态下脂肪代谢改变的主要特征。通过给予外源性脂质乳剂作为代谢燃料来源，可减少脓毒症的内源性分解代谢，尽管与脓毒症相关的脂质代谢变化可能会影响这些外源性脂质的处理。除了限制分解代谢外，脂质乳剂通过改变免疫反应来降低脓毒症相关发病率和死亡率的能力是未来研究的一个令人兴奋的领域。
