Macdonald M J, Horowitz R, Duncan T G
Am J Med Sci. 1975 Mar-Apr;269(2):193-9. doi: 10.1097/00000441-197503000-00005.
The standard lactose tolerance test involves measuring a patient's blood glucose after the ingestion of lactose. If the patient has lactase deficiency and is unable to hydrolyze lactose and absorb its monosaccharides, glucose and galactose, the blood glucose does not usually increase greater than 20 mg/100 ml. Since factors other than the absorption of glucose can cause an increase in the blood glucose of greater than 20 mg/100 ml in a diabetic, this test could be unreliable when it is performed on a diabetic. The present study was performed to determine whether the lactose-ethanol tolerance test could be used to diagnose lactoase deficiency in diabetics. This test involves measuring the blood galactase level, instead of the blood glucose, and the administration of ethyl alcohol to a subject prior to the test to delay the clearance of galactose from the circulation. The results indicate that the standard lactose tolerance test in which the blood glucose is measured is unreliable when performed on insulin-dependent diabetics, but that it can be reliable when performed on non-insulin-dependent diabetics. The lactose-ethanol tolerance test gave results in each type of diabetic which were qualitatively similar to those of nondiabetics. It was concluded that the latter test is a useful screening test for lactase deficiency in diabetics.
标准乳糖耐量试验包括在摄入乳糖后测量患者的血糖。如果患者存在乳糖酶缺乏，无法水解乳糖并吸收其单糖（葡萄糖和半乳糖），血糖通常不会升高超过20毫克/100毫升。由于除葡萄糖吸收之外的因素可导致糖尿病患者血糖升高超过20毫克/100毫升，因此对糖尿病患者进行此项试验可能不可靠。本研究旨在确定乳糖 - 乙醇耐量试验是否可用于诊断糖尿病患者的乳糖酶缺乏。该试验涉及测量血半乳糖水平而非血糖，并在试验前给受试者服用乙醇以延迟半乳糖从循环中的清除。结果表明，对胰岛素依赖型糖尿病患者进行测量血糖的标准乳糖耐量试验不可靠，但对非胰岛素依赖型糖尿病患者进行该试验则可能可靠。乳糖 - 乙醇耐量试验在每种类型糖尿病患者中得出的结果在质量上与非糖尿病患者相似。得出的结论是，后一种试验是筛查糖尿病患者乳糖酶缺乏的有用试验。
