Lerch M M, Rieband H C, Feldberg W, Matern S
Department of Internal Medicine III, Medizinische Fakultät, Rheinisch-Westfälischen Technischen Hochschule, Aachen, BRD.
Digestion. 1991;48(2):81-8. doi: 10.1159/000200677.
In order to collect data on (1) the prevalence of lactose malabsorption and (2) the value of indirect diagnostic methods for hypolactasia in diabetics, we compared lactose tolerance tests using serum glucose, serum galactose (after oral ethanol intake) and breath hydrogen excretion as diagnostic cutoff in 144 nondiabetic and 46 diabetic subjects. A good rate of concordance was found for the hydrogen breath test and galactose-dependent lactose tolerance test. The glucose-dependent lactose tolerance test was found to be of satisfactory diagnostic value in nondiabetic subjects and was useless for diagnostic purposes in diabetics. Lactose malabsorption was no more frequent in diabetics than in controls and lactose intolerance was found to be less frequent in the diabetic group. A distinction between hypolactasia and other gastrointestinal disorders in diabetics is possible by ambulatory indirect tests.
为了收集有关（1）乳糖吸收不良的患病率以及（2）糖尿病患者低乳糖血症间接诊断方法的价值的数据，我们比较了144名非糖尿病患者和46名糖尿病患者以血清葡萄糖、血清半乳糖（口服乙醇后）和呼气氢排泄作为诊断标准的乳糖耐量试验。发现呼气氢试验和半乳糖依赖性乳糖耐量试验的一致性良好。葡萄糖依赖性乳糖耐量试验在非糖尿病患者中具有令人满意的诊断价值，而在糖尿病患者中无诊断用途。糖尿病患者中乳糖吸收不良并不比对照组更常见，且发现糖尿病组中乳糖不耐受的情况较少见。通过动态间接试验可以区分糖尿病患者的低乳糖血症和其他胃肠道疾病。
