Hirase H, Leinekugel X, Czurkó A, Csicsvari J, Buzsáki G
Center for Molecular and Behavioral Neuroscience, Rutgers, State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA.
Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9386-90. doi: 10.1073/pnas.161274398. Epub 2001 Jul 24.
What determines the firing rate of cortical neurons in the absence of external sensory input or motor behavior, such as during sleep? Here we report that, in a familiar environment, the discharge frequency of simultaneously recorded individual CA1 pyramidal neurons and the coactivation of cell pairs remain highly correlated across sleep-wake-sleep sequences. However, both measures were affected when new sets of neurons were activated in a novel environment. Nevertheless, the grand mean firing rate of the whole pyramidal cell population remained constant across behavioral states and testing conditions. The findings suggest that long-term firing patterns of single cells can be modified by experience. We hypothesize that increased firing rates of recently used neurons are associated with a concomitant decrease in the discharge activity of the remaining population, leaving the mean excitability of the hippocampal network unaltered.
在没有外部感觉输入或运动行为的情况下，比如在睡眠期间，是什么决定了皮层神经元的放电频率？在此我们报告，在熟悉的环境中，同时记录的单个CA1锥体神经元的放电频率以及细胞对的共同激活在睡眠-觉醒-睡眠序列中保持高度相关。然而，当在新环境中激活新的神经元组时，这两种测量指标都会受到影响。尽管如此，整个锥体细胞群体的总体平均放电率在行为状态和测试条件下保持不变。这些发现表明，单个细胞的长期放电模式可以被经验改变。我们推测，最近被使用的神经元放电率增加与其余群体放电活动的相应减少有关，从而使海马体网络的平均兴奋性保持不变。
