Study on the correlation of clinical features, pathology and immunohistochemistry of single HGV infection.

OBJECTIVE

Our objective is to study the pathogenicity of the single HGV infection.

METHODS

The ELISA was used to check the serum anti-HGV antibody of 36 cases. Immunohistochemistry staining of hepatic tissue was conducted by using HGV NS5 McAb in 20 single HGV infected patients who were further confirmed by clinical diagnosis and pathological evidence. These patients included 10 cases of acute hepatitis, 7 cases of chronic hepatitis, 1 cases of subacute severe hepatitis and 2 cases of chronic severe hepatitis.

RESULTS

(1) Clinical manifestation: Acute hepatitis occurred abruptly, accompanied with fever, inertia, nausea and sometimes with vomiting and oil disgust. Chronic hepatitis developed slowly and presented mild symptoms. Severe hepatitis presented an acute onset, extreme fatigue, serious gastrointestinal symptoms, or even hepatic coma developed. (2) Changes of ALT and AST: ALT and AST increased slightly in chronic hepatitis and moderately in acute and severe hepatitis. The disproportion between ALT and BiL sometimes occurred in severe hepatitis. (3) Pathological changes in hepatic tissue: Acute hepatitis was characterized by hepatocyte swelling and inflammatory cells infiltrated in portal duct areas. Chronic hepatitis was identified by hepatocyte swelling, piecemeal necrosis or spotty necrosis, slight infiltration of inflammatory cell in portal duct areas and fibrosis. Severe hepatitis appeared as hepatic cell necrosis, inflammatory cell infiltration and slight fibrosis.

CONCLUSIONS

Infection of HGV can give rise to acute hepatitis, chronic hepatitis and severe hepatitis.