Pessac B, Godin I, Alliot F
CNRS-15 rue de l'Ecole de Médecine-75270 Paris.
Bull Acad Natl Med. 2001;185(2):337-46; discussion 346-7.
As suggested by Del Rio Ortega a long time ago, it is now widely accepted that microglia are the resident macrophages of the central nervous system. Microglia represent about 10% of the adult brain cell population. We have previously shown that the late embryonic and adult mouse brain contain potential microglial progenitors. We report here that microglial progenitors can be detected in neural folds from embryonic day 8. They originate from the yolk sac in which macrophage progenitors are found from embryonic day 7. We also report that the bulk of microglial cells (about 95%) appear during post-natal development. A major finding is that microglia arise by an intense in situ proliferation comparable to that of neural cells. Taken together, these results show that adult mouse microglia originate from cells migrating from the yolk sac and whose progeny actively proliferates in the brain during development.
正如很久以前德尔里奥·奥尔特加所指出的，如今人们普遍认为小胶质细胞是中枢神经系统的常驻巨噬细胞。小胶质细胞约占成体脑细胞总数的10%。我们之前已经表明，胚胎晚期和成年小鼠大脑中含有潜在的小胶质细胞祖细胞。我们在此报告，从胚胎第8天起，在神经褶中就能检测到小胶质细胞祖细胞。它们起源于卵黄囊，在胚胎第7天就能在卵黄囊中发现巨噬细胞祖细胞。我们还报告称，大部分小胶质细胞（约95%）在出生后发育过程中出现。一个主要发现是，小胶质细胞通过与神经细胞相当的强烈原位增殖而产生。综上所述，这些结果表明，成年小鼠的小胶质细胞起源于从卵黄囊迁移而来的细胞，其后代在发育过程中在大脑中积极增殖。
