人工消除A组β溶血性链球菌的耐药性。
Artificial elimination of drug resistance from group A beta-hemolytic streptococci.
作者信息
Nakae M, Inoue M, Mitsuhashi S
出版信息
Antimicrob Agents Chemother. 1975 May;7(5):719-20. doi: 10.1128/AAC.7.5.719.
Abstract
Ten strains of beta-hemolytic streptococci were tested for elimination of resistance to macrolide antibiotics, tetracycline, and chloramphenicol. Six of the strains lost resistance after cultivation at 41 C or addition of acriflavine (0.2 mug/ml). These results suggest that determinants governing resistance to these antibiotics are located on extrachromosomal genetic elements (plasmids) that are widely distributed in streptococci.
摘要
对10株β-溶血性链球菌进行了测试，以检测其对大环内酯类抗生素、四环素和氯霉素耐药性的消除情况。其中6株菌株在41℃培养或添加吖啶黄（0.2微克/毫升）后失去了耐药性。这些结果表明，控制对这些抗生素耐药性的决定因素位于广泛分布于链球菌中的染色体外遗传元件（质粒）上。
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