流感嗜血杆菌中质粒介导的氯霉素耐药性。
Plasmid-mediated chloramphenicol resistance in Haemophilus influenzae.
作者信息
van Klingeren B, van Embden J D, Dessens-Kroon M
出版信息
Antimicrob Agents Chemother. 1977 Mar;11(3):383-7. doi: 10.1128/AAC.11.3.383.
Abstract
A clinical isolate of Haemophilus influenzae HC234 was found to be resistant to chloramphenicol and tetracycline. It was shown that both resistance markers are tranferable as one unit to other Haemophilus influenzae strains and also to Escherichia coli. Data are presented which indicate that conjugation is the most likely mechanism of resistance transfer. HC234 was shown to carry a single plasmid species with a molecular weight of 38 x 10(6).
摘要
一株流感嗜血杆菌临床分离株HC234被发现对氯霉素和四环素耐药。结果表明，这两种耐药标记可作为一个单位转移至其他流感嗜血杆菌菌株，也可转移至大肠杆菌。所提供的数据表明，接合是耐药性转移最可能的机制。HC234被证明携带一种分子量为38×10⁶的单一质粒。
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