生长激素对生理刺激反应的选择性受损。
Selective impairment of growth hormone response to physiological stimuli.
作者信息
Wise P H, Burnet R B, Geary T D, Berriman H
出版信息
Arch Dis Child. 1975 Mar;50(3):210-4. doi: 10.1136/adc.50.3.210.
Abstract
In a consecutive group of 25 children with defective growth being evaluated for growth hormone deficiency, EEG-monitored slow-wave sleep provided discriminatory serum growth hormone responses equivalent to those obtained by arginine and insulin-hypoglycaemia provocation. Exercise was less effective but was able to provide a useful screening test. In 2 subjects with abnormal physiological but normal pharmacological serum growth hormone responses, therapeutic administration of growth hormone in one resulted in a significant growth increment, whereas in the other, advanced epiphyseal maturity precluded adequate evaluation. A normal growth hormone response to a pharmacological stimulus does not exclude a therapeutic response to human growth hormone.
摘要
在一组连续的25名生长发育不良且正在接受生长激素缺乏评估的儿童中，脑电图监测的慢波睡眠所提供的血清生长激素反应具有鉴别意义，等同于精氨酸和胰岛素低血糖激发试验所获得的反应。运动效果较差，但可提供一项有用的筛查试验。在2名生理反应异常但药物刺激后血清生长激素反应正常的受试者中，其中1名接受生长激素治疗后生长显著增加，而另1名因骨骺成熟提前而无法进行充分评估。对药物刺激的生长激素反应正常并不能排除对人生长激素的治疗反应。
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本文引用的文献
1
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Electroencephalogr Clin Neurophysiol. 1957 Nov;9(4):673-90. doi: 10.1016/0013-4694(57)90088-3.
2
Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965. II.1965年英国儿童从出生到成年的身高、体重、身高增长速度和体重增长速度标准：第二部分。
Arch Dis Child. 1966 Dec;41(220):613-35. doi: 10.1136/adc.41.220.613.
3
Growth hormone secretion during sleep.睡眠期间的生长激素分泌。
J Clin Invest. 1968 Sep;47(9):2079-90. doi: 10.1172/JCI105893.
4
Growth and growth hormone. I. Changes in serum level of growth hormone following hypoglycemia in 134 children with growth retardation.生长与生长激素。I. 134例生长迟缓儿童低血糖后生长激素血清水平的变化
Pediatr Res. 1968 Jan;2(1):43-63. doi: 10.1203/00006450-196801000-00005.
5
Effect of human growth hormone treatment for 1 to 7 years on growth of 100 children, with growth hormone deficiency, low birthweight, inherited smallness, Turner's syndrome, and other complaints.对100名患有生长激素缺乏症、低出生体重、遗传性身材矮小、特纳综合征及其他病症的儿童进行1至7年生长激素治疗的效果
Arch Dis Child. 1971 Dec;46(250):745-82. doi: 10.1136/adc.46.250.745.
6
Exercise as a screening test for growth hormone release.
Acta Endocrinol (Copenh). 1972 Feb;69(2):219-29. doi: 10.1530/acta.0.0690219.
7
Sleep related human growth hormone (GH) release: a test of physiologic growth hormone secretion in children.与睡眠相关的人类生长激素（GH）释放：一项儿童生理性生长激素分泌的测试。
J Clin Endocrinol Metab. 1972 Feb;34(2):339-41. doi: 10.1210/jcem-34-2-339.
8
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9
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