[Combination chemotherapy of 5-fluorouracil and nitrocaphane for the treatment of malignant trophoblastic tumor].

OBJECTIVE

To evaluate the effectiveness, side effects and long term result of combination protocol of 5-fluorouracil (5-FU) and nitrocaphane (AT1258) on patients with malignant trophoblastic tumor.

METHODS

The chart and follow up data of 166 patients treated from 1979 to 1988 in Liaoning Province Tumor Hospital were reviewed. 136 invasive mole and 30 choriocarcinoma were treated by a 5-FU and AT1258 combined protocol. Their immediate treatment results, side effects and long-term follow-ups were retrospectively analysed.

RESULTS

The complete remission rate of invasion mole was 100.0% and choriocarcinoma 86.7%. The accumulative 5 and 10 year's survival rate for invasive mole were 100.0% and 99.3%, while 85.8% and 85.8% for choriocarcinoma. None of this group died of side effects or complication.

CONCLUSION

5-FU and AT1258 combination chemotherapy may be a protocol of choice in the treatment of malignant trophoblastic tumor.