低剂量（1毫克和2毫克）静脉注射普萘洛尔对急性心肌梗死血流动力学影响的评估。
Evaluation of haemodynamic effects of intravenous propranolol at low dosage (1 and 2 mg) in acute myocardial infarction.
作者信息
Letac B, Letournel J
出版信息
Br Heart J. 1975 Jun;37(6):624-8. doi: 10.1136/hrt.37.6.624.
Abstract
The haemodynamic effects of intravenous propranolol at low dosage (1 and 2 mg) have been evaluated on 14 patients in the acute stage of myocardial infarction. The first 1 mg propranolol was not followed by any significant variation in the variables measured. After the second 1 mg propranolol, the heart rate, cardiac index, and stroke index decreased significantly but moderately. Changes in pulmonary wedge pressure were not significant. It is concluded that intravenous propranolol in the small dosage of 1 or 2 mg, at which antiarrhythmic effect is still produced, has only a negligible depressant myocardial effect.
摘要
已对14例处于心肌梗死急性期的患者评估了静脉注射低剂量（1毫克和2毫克）普萘洛尔的血流动力学效应。首次注射1毫克普萘洛尔后，所测变量未出现任何显著变化。第二次注射1毫克普萘洛尔后，心率、心脏指数和每搏指数显著但适度下降。肺楔压变化不显著。得出的结论是，静脉注射1或2毫克小剂量普萘洛尔，在仍能产生抗心律失常作用的情况下，仅具有可忽略不计的心肌抑制作用。
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