布立马胺对小猫离体心房的间接拟交感神经效应。
An indirect sympathomimetic effect of burimamide on kitten isolated atria.
作者信息
Hood A J, Smy J R, Weetman D F
出版信息
Br J Pharmacol. 1975 Apr;53(4):525-9. doi: 10.1111/j.1476-5381.1975.tb07390.x.
Abstract
- Burimamide (34-1080 muM) caused a concentration-dependent increase in the force and frequency of contraction of kitten isolated atria. 2. Metiamide (467 muM) had no stimulant action on kitten atria and did not modify the effects of burimamide. 3. The atrial stimulation produced by burimamide was reduced by (-)propranolol (34-68 nM) and by cocaine (3 muM). 4. The atrial stimulant effect of burimamide was prevented by pretreatment of kittens with reserpine (1 mg/kg, 24 h before the experiment). 5. It is concluded that burimamide causes atrial stimulation by releasing catecholamines.
摘要
- 布立马胺（34 - 1080微摩尔）使新生小猫离体心房的收缩力和频率呈浓度依赖性增加。2. 甲硫咪胺（467微摩尔）对新生小猫心房无刺激作用，也不改变布立马胺的作用。3. 布立马胺引起的心房刺激作用被（-）普萘洛尔（34 - 68纳摩尔）和可卡因（3微摩尔）减弱。4. 利血平（1毫克/千克，实验前24小时）预处理新生小猫可阻止布立马胺的心房刺激作用。5. 结论是布立马胺通过释放儿茶酚胺引起心房刺激。
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