Hardy-Smith A, Shields R
Br J Surg. 1975 Jun;62(6):455-61. doi: 10.1002/bjs.1800620608.
The rates of transport of potassium, sodium and water across the intestinal mucosa of Thiry-Vella fistulas of colon and ileum, were studied in dogs in two experimental situations; (1) following intravenous infusion of potassium (15 mEg) over 30 minutes and (2) during variations in the intraluminal concentration of potassium in the range 0.8-16.0 mEg/l. Following intravenous infusion of potassium the rates of potassium secretion into the colon were usually increased; the rates of sodium and water absorption were either unchanged or decreased. The unidirectional rate of movement of potassium into the lumen increased as the concentration difference across the mucosa increased; the movement of potassium in the opposite direction remained relatively constant. The undirectional movement of sodium and water into the lumen of the colon also increased but to a lesser extent. The effect on potassium transport in the ileum was not so marked. With increase in the intraluminal concentration of potassium there was a decrease in the rate of net potassium secretion in both colon and ileum. The rates of net absorption of sodium and water were not significantly altered. Unidirectional potassium movement into the body increased in all the ileal fistulas.
在两种实验情况下，对犬结肠和回肠的Thiry-Vella瘘管肠黏膜中钾、钠和水的转运速率进行了研究：（1）在30分钟内静脉输注钾（15毫当量）后；（2）管腔内钾浓度在0.8 - 16.0毫当量/升范围内变化时。静脉输注钾后，结肠中钾的分泌速率通常会增加；钠和水的吸收速率要么不变，要么降低。随着跨黏膜浓度差的增加，钾向肠腔的单向移动速率增加；钾向相反方向的移动保持相对恒定。钠和水向结肠腔的单向移动也增加，但程度较小。对回肠中钾转运的影响不那么明显。随着管腔内钾浓度的增加，结肠和回肠中钾的净分泌速率均降低。钠和水的净吸收速率没有显著改变。在所有回肠瘘管中，钾向体内的单向移动均增加。
