Pajares J M, Gisbert J P
Servicio de Aparato Digestivo, Hospital Universitario de la Princesa, Madrid, Spain.
Rev Esp Enferm Dig. 2001 Jan;93(1):9-20.
Incidence and prevalence of Inflammatory Bowel Disease (IBD) differ considerably depending on the geographical region studied. In Spain, both Ulcerative Colitis (UC) and Crohn's Disease (CD) seem to have experienced an important change in terms of incidence during the past decades. Our aim was to systematically review the experience in Spain regarding the epidemiology of IBD, in particular its incidence, its geographical differences and its evolution over time.
A bibliographical search till January 2000 was conducted in Internet using the PubMed search motor and the following descriptors or key words: "Crohn's disease", "Ulcerative colitis", "Inflammatory bowel disease", "Spain" and "Spanish". Only publications providing data on IBD incidence among Spanish patients were included. References from articles that fulfilled the selection criteria were also reviewed. The endpoints considered in the review were IBD incidence rate, its geographical differences, and its evolution over time.
UC incidence reported by different studies performed in Spain ranges from 0.6 to 8 cases/10(5)/year, with a mean value of 3.8. CD incidence rates in Spain ranges from 0.4 to 5.5 cases/105/year, with a mean value of 1.9. Some studies have shown differences in IBD incidence between regions in our country. Many studies have reported an increase in IBD incidence in Spain over time, although such increase is more evident in the case of CD.
UC incidence in Spain ranges from 0.6 to 8 cases/105/year, with a mean value of 3.8. CD figures range from 0.4 to 5.5 cases/105/year, with an average rate of 1.9. IBD incidence seems to be relatively different depending on the geographical region studied. Finally, several authors have demonstrated an increase in IBD incidence in Spain over time, although such increase seems to be more evident in the case of CD. Consequently, IBD in Spain is no longer considered a rare disease, but a relatively frequent one.
炎症性肠病（IBD）的发病率和患病率因所研究的地理区域不同而有很大差异。在西班牙，过去几十年间，溃疡性结肠炎（UC）和克罗恩病（CD）的发病率似乎都发生了显著变化。我们的目的是系统回顾西班牙关于IBD流行病学的经验，特别是其发病率、地理差异以及随时间的演变。
截至2000年1月，利用PubMed搜索引擎在互联网上进行文献检索，并使用以下描述词或关键词：“克罗恩病”、“溃疡性结肠炎”、“炎症性肠病”、“西班牙”和“西班牙语”。仅纳入提供西班牙患者IBD发病率数据的出版物。还对符合选择标准的文章的参考文献进行了回顾。本综述中考虑的终点是IBD发病率、其地理差异以及随时间的演变。
西班牙不同研究报告的UC发病率为每年0.6至8例/10⁵，平均值为3.8。西班牙的CD发病率为每年0.4至5.5例/10⁵，平均值为1.9。一些研究表明我国不同地区的IBD发病率存在差异。许多研究报告称西班牙IBD的发病率随时间有所增加，尽管这种增加在CD病例中更为明显。
西班牙UC发病率为每年0.6至8例/10⁵，平均值为3.8。CD发病率为每年0.4至5.5例/10⁵，平均发病率为1.9。IBD发病率似乎因所研究的地理区域而相对不同。最后，几位作者证明西班牙IBD的发病率随时间有所增加，尽管这种增加在CD病例中似乎更为明显。因此，IBD在西班牙不再被视为罕见疾病，而是一种相对常见的疾病。
