Vahlsing H L, Feringa E R, Britten A G, Kinning W K
Cancer Res. 1975 Aug;35(8):2199-202.
Delayed drug-related mortality in rats treated with a single high dose (75 mg/kg) of cyclophosphamide complicated experiments using this drug treatment. We observed that this delayed mortality was due to dental abnormalities including broken teeth, absent teeth, extra long teeth, and/or supernumerary teeth. These dental abnormalities developed about 140 days after treatment and, if left untreated, interfered with eating. Eventually, the untreated rats starved. Clipping their long teeth and feeding the rats powdered chow eliminated the deaths. Researchers should be aware that high doses of cyclophosphamide may result in dental abnormalities several months after the treatment.
用单次高剂量（75毫克/千克）环磷酰胺处理的大鼠出现与药物相关的延迟性死亡，这给使用该药物治疗的实验带来了复杂性。我们观察到这种延迟性死亡是由于牙齿异常，包括断牙、无牙、牙齿过长和/或多生牙。这些牙齿异常在治疗后约140天出现，如果不进行治疗，会影响进食。最终，未治疗的大鼠饿死。剪掉它们的长牙并给大鼠喂食粉状食物可避免死亡。研究人员应意识到，高剂量环磷酰胺可能在治疗数月后导致牙齿异常。
