Vahlsing H L, Kim S K, Feringa E R
J Dent Res. 1977 Jul;56(7):809-16. doi: 10.1177/00220345770560071601.
A single injection of 75 mg/kg cyclophosphamide caused gross dental abnormalities in rats. Broken, malformed, overgrown, and "extra" incisors developed several weeks after drug treatment. Radioautographic investigations show no unusual features in the morphology or labeling with H3-thymidine in the odontogenic cells. The results suggest that the cytotoxic effect of the drug is a temporary one which induces a residual alteration of tooth growth.
单次注射75毫克/千克的环磷酰胺会导致大鼠出现明显的牙齿异常。在药物治疗几周后，大鼠的门牙出现了断裂、畸形、过度生长以及“额外”生长的情况。放射自显影研究表明，牙源性细胞在形态或用H3-胸腺嘧啶核苷标记方面没有异常特征。结果表明，该药物的细胞毒性作用是暂时的，会导致牙齿生长的残留改变。
