Wada K, Niimi A, Watanabe K, Sawai T, Ueda M
Department of Oral and Maxillofacial Surgery, Nagoya University Postgraduate School of Medicine, Nagoya, Japan.
Int J Periodontics Restorative Dent. 2001 Jun;21(3):252-63.
The present study was designed to compare recombinant human bone morphogenetic protein-2 (rhBMP-2) impregnated on an absorbable collagen sponge (ACS) with particulate cancellous bone and marrow (PCBM) harvested from the iliac crest in an animal model of maxillary sinus floor augmentation. Bilateral sinus floor augmentation procedures were performed in 30 adult Japanese white rabbits. rhBMP-2/ACS or PCBM was grafted to each maxillary sinus. Animals were sacrificed at 2, 4, or 8 weeks after grafting, and bone formation in response to each implant was evaluated histologically and histometrically. Histometric results compared by analysis of variance revealed no statistically significant difference in the bone volume at augmented areas between the two types of implant (P > 0.05). Histologic evaluation documented that the trabeculae with a lamellar structure were embedded in fatty marrow at 8 weeks in both implant sites. These results suggest that sinus floor augmentation with rhBMP-2/ACS or PCBM induces comparable histologic and histometric evidence of bone formation in rabbits.
本研究旨在比较在上颌窦底提升动物模型中，负载于可吸收胶原海绵（ACS）上的重组人骨形态发生蛋白-2（rhBMP-2）与取自髂嵴的颗粒状松质骨和骨髓（PCBM）。对30只成年日本白兔进行双侧窦底提升手术。将rhBMP-2/ACS或PCBM移植到每个上颌窦。在移植后2、4或8周处死动物，通过组织学和组织计量学评估每种植入物引起的骨形成。通过方差分析比较的组织计量学结果显示，两种植入物在提升区域的骨体积上无统计学显著差异（P>0.05）。组织学评估表明，在两个植入部位，8周时具有板层结构的小梁均嵌入脂肪骨髓中。这些结果表明，rhBMP-2/ACS或PCBM进行窦底提升在兔中诱导出相当的骨形成组织学和组织计量学证据。
