Joo Myung-Jae, Cha Jae-Kook, Lim Hyun-Chang, Choi Seong-Ho, Jung Ui-Won
Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea.
Department of Periodontology, Kyung Hee University School of Dentistry, Seoul, Korea.
J Periodontal Implant Sci. 2017 Apr;47(2):86-95. doi: 10.5051/jpis.2017.47.2.86. Epub 2017 Apr 29.
The aim of this study was to determine the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded synthetic bone substitute on implants that were simultaneously placed with sinus augmentation in rabbits.
In this study, a circular access window was prepared in the maxillary sinus of rabbits (n=5) for a bone graft around an implant (Ø 3×6 mm) that was simultaneously placed anterior to the window. Synthetic bone substitute loaded with rhBMP-2 was placed on one side of the sinus to form the experimental group, and saline-soaked synthetic bone substitute was placed on the other side of the sinus to form the control group. After 4 weeks, sections were obtained for analysis by micro-computed tomography and histology.
Volumetric analysis showed that the median amount of newly formed bone was significantly greater in the BMP group than in the control group (51.6 mm and 46.6 mm, respectively; =0.019). In the histometric analysis, the osseointegration height was also significantly greater in the BMP group at the medial surface of the implant (5.2 mm and 4.3 mm, respectively; =0.037).
In conclusion, an implant simultaneously placed with sinus augmentation using rhBMP-2-loaded synthetic bone substitute can be successfully osseointegrated, even when only a limited bone height is available during the early stage of healing.
本研究旨在确定负载重组人骨形态发生蛋白-2（rhBMP-2）的合成骨替代物对在兔中与鼻窦增大同时植入的种植体的影响。
在本研究中，在兔（n = 5）的上颌窦中制备圆形进入窗口，用于在窗口前方同时植入的种植体（Ø 3×6 mm）周围进行骨移植。将负载rhBMP-2的合成骨替代物放置在鼻窦的一侧以形成实验组，将盐水浸泡的合成骨替代物放置在鼻窦的另一侧以形成对照组。4周后，获取切片进行微计算机断层扫描和组织学分析。
体积分析显示，BMP组新形成骨的中位数明显大于对照组（分别为51.6 mm和46.6 mm；P = 0.019）。在组织计量学分析中，种植体内侧表面的骨结合高度在BMP组中也明显更高（分别为5.2 mm和4.3 mm；P = 0.037）。
总之，即使在愈合早期仅有有限的骨高度时，使用负载rhBMP-2的合成骨替代物与鼻窦增大同时植入的种植体也能成功实现骨结合。
