Henderson J N, Tait I B
Curr Med Res Opin. 1975;3(3):157-62. doi: 10.1185/03007997509113664.
One hundred and thirty-five women suffering from trichomonal, candidal, or both infections simultameously, were treated with povidone-iodine pessaries, 2 pessaries being inserted nightly. Ninety-nine women were given a 7-day course of treatment, but the results obtained were disappointing, and the authors do not recommend such a regime for routine treatment. Better results were obtained with the recommended 14-day course. A further 36 women suffering from chronic trichomonal and/or canidal infections which had previously resisted orthodox treatment were given a prolonged 28-day course of pessary treatment. The results obtained were very encouraging, 92% of the trichomonal and 96% of the canidal infections being cured. Furthermore, although povidone-iodine is slightly less effective in trichomoniasis, most patients suffering from a chronic infection (candidal, as well as trichomonal) were cured by the one preparation. Side-effects did occur, but were significant in only 3 patients. Subjective symptoms, especially any offensive odour, disappeared within 3 days of the start of the treatment. The authors recommend that the 28-day course of povidone-iodine pessaries is used in those cases where trichomoniasis or candidosis has been a therapeutic problem in the past, particularly if the patient is currently on the oral contraceptive pill.
135名同时患有滴虫感染、念珠菌感染或两者皆有的女性患者，接受了聚维酮碘阴道栓剂治疗，每晚塞入2枚栓剂。99名女性接受了为期7天的疗程治疗，但结果令人失望，作者不推荐这种治疗方案用于常规治疗。采用推荐的14天疗程获得了更好的效果。另外36名患有慢性滴虫和/或念珠菌感染且先前对传统治疗有抵抗的女性，接受了为期28天的延长阴道栓剂治疗疗程。获得的结果非常令人鼓舞，滴虫感染的治愈率为92%，念珠菌感染的治愈率为96%。此外，尽管聚维酮碘在滴虫病中的疗效略低，但大多数患有慢性感染（念珠菌感染以及滴虫感染）的患者通过单一制剂得到了治愈。确实出现了副作用，但仅3名患者有明显副作用。主观症状，尤其是任何异味，在治疗开始后3天内消失。作者建议，对于过去滴虫病或念珠菌病一直是治疗难题的病例，特别是如果患者目前正在服用口服避孕药，应采用为期28天的聚维酮碘阴道栓剂疗程。
