Krueger W W, Goepfert H, Romsdahl M, Herson J, Withers R H, Jesse R H
Otolaryngology. 1978 Sep-Oct;86(5):ORL-804-11. doi: 10.1177/019459987808600527.
Irradiation of normal tissues at the dose/time factor employed in the treatment of solid tumors impairs the subsequent healing of surgical wounds made in those tissues. Irreversible radiation damage to regional fibroblasts is one cause of impaired healing. This study was conducted to determine whether syngeneic guinea pig fibroblasts, harvested from tissue culture when injected into irradiated guinea pig skin at the time of wound closure, could improve wound healing. Breaking strength determinations indicate that irradiated wounds demonstrate enhanced wound healing if implanted with fibroblasts.
以实体瘤治疗中使用的剂量/时间因子对正常组织进行照射，会损害这些组织中手术伤口的后续愈合。局部成纤维细胞的不可逆辐射损伤是愈合受损的一个原因。本研究旨在确定，在伤口闭合时将从组织培养中收获的同基因豚鼠成纤维细胞注射到受照射的豚鼠皮肤中，是否能够改善伤口愈合。抗张强度测定表明，如果植入成纤维细胞，受照射的伤口显示出伤口愈合增强。
