Yi B D, Ma B, Xing B R
Department of Physiology, Second Military Medical University, Shanghai 200433.
Sheng Li Xue Bao. 1999 Apr;51(2):147-52.
Rapid effects of hydrocortisone 21-hemisuccinate (F-suc) on cholinergic synaptic transmission of B neurons in bullfrog sympathetic ganglia (BFSG) were studied with intracellular recording technique in vitro. The main results are as follows: (1) F-suc blocked cholinergic synaptic transmission of 52 B neurons within 0.5-3 min, which was concentration-dependent and partially suppressed by the cytoplasm receptor antagonist of steroid hormones, RU38486; (2) after protein synthesis was suppressed by actidione, the above effect persisted; and (3) the effect of F-suc could be potentiated by atropine. All these results suggest that the F-suc induced rapid effects of cholinergic synaptic transmission of B neurons in BFSG may be mediated by non-genomic mechanisms.
采用体外细胞内记录技术，研究了氢化可的松21 - 半琥珀酸酯（F - suc）对牛蛙交感神经节（BFSG）中B神经元胆碱能突触传递的快速作用。主要结果如下：（1）F - suc在0.5 - 3分钟内阻断了52个B神经元的胆碱能突触传递，呈浓度依赖性，且被甾体激素的细胞质受体拮抗剂RU38486部分抑制；（2）放线菌酮抑制蛋白质合成后，上述作用仍然存在；（3）阿托品可增强F - suc的作用。所有这些结果表明，F - suc诱导的BFSG中B神经元胆碱能突触传递的快速作用可能由非基因组机制介导。
